Extrachromosomal DNAs (ecDNAs) are a pervasive feature found in cancer and contain oncogenes and their corresponding regulatory elements.Their unique structural properties allow a rapid amplification of oncogenes and alter chromatin accessibility, leading to tumorigenesis and malignant development.The uneven segregation of ecDNA during cell divisio
An increasing number of Conditionally Automated Driving (CAD) systems are being developed by major automotive manufacturers.In a CAD system, the automated system is in control of the vehicle within its operational design domain.Therefore, in CAD the vehicle is capable of tactical control of the vehicle and needs to be able End Table to maneuver eva
This review recounts the origins and development of the concept of the hypothalamic gonadotropin-releasing hormone (GnRH) pulse generator.It starts in the late 1960s when striking rhythmic episodes of Magnets luteinizing hormone secretion, as reflected by circulating concentrations of this gonadotropin, were first observed in monkeys and ends in th
This study examined the effect of flexible work arrangements on productivity of sales representatives of book publishing companies in Nigeria.The specific objectives of the study were; to examine the relationship between flexi-time, job sharing, part time and telecommuting and employee effectiveness and employee efficiency of sales representatives